Arterolane
Encyclopedia
Arterolane, also known as OZ277 or RBx 11160, is a substance being tested for antimalarial
activity by Ranbaxy Laboratories
. Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide
group and an adamantane
substituent.
Phase III clinical trials of arterolane, in combination with piperaquine
, began in India in 2009.
Antimalarial drug
Antimalarial medications, also known as antimalarials, are designed to prevent or cure malaria. Such drugs may be used for some or all of the following:* Treatment of malaria in individuals with suspected or confirmed infection...
activity by Ranbaxy Laboratories
Ranbaxy Laboratories
Ranbaxy Laboratories Limited is a pharmaceutical company that was incorporated in India in 1961. The company went public in 1973 and Japanese pharmaceutical company Daiichi Sankyo gained majority control in 2008...
. Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide
Ozonide
Ozonide is an unstable, reactive polyatomic anion O3−, derived from ozone, or an organic compound similar to organic peroxide formed by a reaction of ozone with an unsaturated compound.-Inorganic ozonides:...
group and an adamantane
Adamantane
Adamantane is a colorless, crystalline chemical compound with a camphor-like odor. With a formula C10H16, it is a cycloalkane and also the simplest diamondoid. Adamantane molecules consist of three cyclohexane rings arranged in the "armchair" configuration. It is unique in that it is both rigid...
substituent.
Phase III clinical trials of arterolane, in combination with piperaquine
Piperaquine
Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based...
, began in India in 2009.