Anatabine
Encyclopedia
Anatabine is one of the minor alkaloids found in plants in the Solanaceae
family, which includes the tobacco plant, that has been shown to affect monoamine oxidase (MAO) activity
. Anatabine is found in cigarette tobacco and smoke, and is absorbed in the human body after tobacco use.
There have been hypotheses that minor tobacco constituents and other non-nicotine therapies may be beneficial in fighting nicotine withdrawal. Many studies have been conducted investigating the effects of smoking on MAO activity.
Anatabine is one of the ingredients in the smoking alternative dietary supplement, CiGRX, developed by Rock Creek Pharmaceuticals. The use of anatabine rather than nicotine replacement therapy is related to the half-lives of nicotine and anatabine. The latency of needing a cigarette (LTNC) among regular smokers was less than two hours compared to the half-life of anatabine which is 10 hours.
Rock Creek Pharmaceuticals has also developed Anatabloc, a product that targets inflammation. The Roskamp Institute in Sarasota, Florida, has worked with Rock Creek Pharmaceuticals to study the effects of the anatabine compound on inflammatory diseases and disorders. Roskamp findings can be viewed at The Roskamp Institute Website.
Anatabine's potential in fighting Alzheimer's disease and other anti-inflammatory illnesses is being studied.
Solanaceae
Solanaceae are a family of flowering plants that include a number of important agricultural crops as well as many toxic plants. The name of the family comes from the Latin Solanum "the nightshade plant", but the further etymology of that word is unclear...
family, which includes the tobacco plant, that has been shown to affect monoamine oxidase (MAO) activity
Monoamine oxidase
L-Monoamine oxidases are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by Mary Bernheim in the liver and was named tyramine oxidase...
. Anatabine is found in cigarette tobacco and smoke, and is absorbed in the human body after tobacco use.
There have been hypotheses that minor tobacco constituents and other non-nicotine therapies may be beneficial in fighting nicotine withdrawal. Many studies have been conducted investigating the effects of smoking on MAO activity.
Anatabine is one of the ingredients in the smoking alternative dietary supplement, CiGRX, developed by Rock Creek Pharmaceuticals. The use of anatabine rather than nicotine replacement therapy is related to the half-lives of nicotine and anatabine. The latency of needing a cigarette (LTNC) among regular smokers was less than two hours compared to the half-life of anatabine which is 10 hours.
Rock Creek Pharmaceuticals has also developed Anatabloc, a product that targets inflammation. The Roskamp Institute in Sarasota, Florida, has worked with Rock Creek Pharmaceuticals to study the effects of the anatabine compound on inflammatory diseases and disorders. Roskamp findings can be viewed at The Roskamp Institute Website.
Anatabine's potential in fighting Alzheimer's disease and other anti-inflammatory illnesses is being studied.