Amino acid response is the mechanism triggered in mammalian cells by amino acid starvation.

The amino acid response pathway is triggered by shortage of any essential amino acid, and results in an increase in activating transcription factor

Activating transcription factor

In molecular biology, activating transcription factor, ATF, is a class of AP-1 transcription factor dimers.Genes include ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7....

 ATF4

ATF4

Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.- Function :...

, which in turn affect many process by sundry pathways to limit or increase the production of other proteins.

Proteins increased by AAR

• Membrane transporters
• Transcription factor
  Transcription factor
  In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
  
  s from the basic region/leucine zipper
  Leucine zipper
  A leucine zipper, aka leucine scissors, is a common three-dimensional structural motif in proteins. These motifs are usually found as part of a DNA-binding domain in various transcription factors, and are therefore involved in regulating gene expression...
  
   (bZIP) superfamily
• Growth factor
  Growth factor
  A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes....
  
  s
• Metabolic enzymes

Leucine starvation

PCAF

PCAF

P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...

 is recruited specifically to the CHOP

CHOP

CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:* Cyclophosphamide, an alkylating agent which damages DNA by binding to it and causing cross-links...

amino acid response element (AARE) to enhance the ATF4 transcriptional activity.