As of the 2010 census Adrian had a population of 21,133. The racial and ethnic makeup of the population was 84.1% white, 4.4% black or African American, 0.6% Native American, 0.9% Asian, 5.9% from some other race and 4.0% from two or more races. 18.8% of the population was Hispanic or Latino of any race.

As of the census

Census

A census is the procedure of systematically acquiring and recording information about the members of a given population. It is a regularly occurring and official count of a particular population. The term is used mostly in connection with national population and housing censuses; other common...

of 2000, there were 21,574 people, 7,908 households, and 4,855 families residing in the city.