362    A mysterious fire destroys the temple of Apollo at Daphne outside Antioch.

363    Roman Emperor Julian moves from Antioch with an army of 90,000 to attack the Sassanid Empire, in a campaign which would bring about his own death.

526    An earthquake kills about 300,000 people in Syria and Antiochia.

526    A devastating earthquake strikes Antioch, Turkey, killing 250,000.

969    Byzantine troops occupy Antioch Syria

1098    First Crusade: Antioch falls to the crusaders after an eight-month siege.