48 Battle in Alexandria, Egypt between the forces of Caesar and his ally Cleopatra VII of Egypt and those of rival King Ptolemy XIII of Egypt and Queen Arsinoe IV. The latter two are defeated and flee the city, but during the battle part of the Library of Alexandria catches fire and is burned down.
47 Roman general Julius Caesar and his ally Cleopatra VII of Egypt defeat the forces of the rival Egyptian Queen Arsinoe IV in the Battle of the Nile. Ptolemy is killed; Caesar then relieves his besieged forces in Alexandria.
30 Octavian captures Alexandria. This marks the official annexation of Ancient Egypt to the Roman Republic.
38 Apion heads a deputation to Caligula to complain about the Jews in Alexandria.
38 Anti-Jewish riot breaks out in Alexandria during a visit by Agrippa I: the mob wants to place statues of Caligula in every synagogue.
39 Philo leads a Jewish delegation to Rome to protest the anti-Jewish conditions in Alexandria.
40 Christianity comes to Egypt as a church is founded in Alexandria. Mark the Evangelist founds the Coptic Orthodox Church as the first pope.
54 Under Nero, Rome annexes Aden to protect the maritime route between Alexandria and Asia.
98 In order to maintain the Port of Alexandria, Trajan reopens the canal between the Nile and the Red Sea.
189 Pantaenus, who was sent by the bishop of Alexandria to India to preach Christianity, meets with little success.
203 Origenes replaces Clement as the head of the Christian school in Alexandria.
216 Caracalla dreams of renewing the Asian exploits of Alexander the Great. When the Greeks in Alexandria mock his claims, he kills a number of them.
249 In Alexandria, the populace pillages the homes of Christians.
269 The library at Alexandria is burned down during a raid by Zabdas, general of Zenobia.
292 The Roman General Achilleus is proclaimed emperor in Alexandria. For two years he resists Diocletian's army, but in the end the rebellion is crushed.
321 A synod in Alexandria condemns Arianism.
362 Athanasius returns to Alexandria.
365 Emperor Valens exiles Athanasius from Alexandria.
380 Roman Emperors Theodosius I and Gratianus declare that the patriarchs of Rome and Alexandria hold primacy (above especially the one of Constantinople), implicitly rejecting Arianism in favor of orthodox Christianity.
385 The Serapeum in Alexandria is destroyed.
385 Theophilus of Alexandria becomes patriarch of Alexandria.
415 The Jews are expelled from Alexandria.
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616 Alexandria is captured by Khosrau II of Persia.
641 Alexandria formally surrendered to Amr ibn al-As by a treaty signed on November 8.
860 Michael I succeeds Sophronius I as patriarch of Alexandria.
1166 Marko III succeeds Yoannis V as patriarch of Alexandria.
1365 The city of Alexandria in Egypt is sacked by an allied force of Peter I of Cyprus and the knights of the Order of St. John of Jerusalem.
1688 Gerasimus I succeeds Parthenius I as Patriarch of Alexandria.
1882 British troops occupy Alexandria and Suez Canal
1921 May 17 - Violent anti-European riots in Cairo and Alexandria