Metrazol
Metrazol is the commercial trademark of pentamethylenetetrazol, or pentylenetetrazol , a drug used as a circulatory and respiratory stimulant . Larger doses cause convulsions, thus it has been used in shock therapy, as discovered by the Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934.
It is considered a non-competitive GABA antagonist. The mechanism of the epileptogenic action of PTZ at the cellular
neuronal level is still unclear.
Electrophysiological studies have shown it acts at
cell membrane level decreasing the recovery time between
action potentials by increasing
potassium permeability of the axon.
Encyclopedia
Metrazol is the commercial trademark of pentamethylenetetrazol, or pentylenetetrazol , a drug used as a circulatory and respiratory stimulant . Larger doses cause convulsions, thus it has been used in shock therapy, as discovered by the Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934.
It is considered a non-competitive GABA antagonist. The mechanism of the epileptogenic action of PTZ at the cellular
neuronal level is still unclear.
Electrophysiological studies have shown it acts at
cell membrane level decreasing the recovery time between
action potentials by increasing
potassium permeability of the axon. Other studies have implicated an increase in membrane currents of several other ions, such as
sodium and calcium, leading to an overall increase in excitability of the neuron membrane.
Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.PTZ is also a prototypical anxiogenic drug and, has been extensively utilized in animal models of anxiety. PTZ produces a reliable discriminative stimulus which is largely mediated by the GABAA receptor. Several classes of compounds can modulate the PTZ discriminative stimulus including 5-HT1A, 5-HT3,
NMDA,
glycine, and L-type calcium channel ligands.
See also
References
